Expert Knowledge

Medical focuses

The major task of histopathology is the examination of tissue samples (needle and endoscopic biopsies, surgical biopsies, resection specimen). The aim is a precise diagnosis to serve as a basis for decisions on further diagnostic procedures or therapy.
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Intraoperative diagnostics
During surgery tissue samples can be examined and diagnosis rendered within minutes, either by frozen section technique or imprint cytology. Diagnoses are provided that have an immediate impact an decisions taken during the surgical procedure.
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In cytology the analysis of single cells can lead to a diagnosis. These cells can be recovered from bodily fluids (urine) or effusions (ascites, pleura), and from tissue scrapings, or they can be obtained by fine needle aspiration technique. Cytology can serve as a screening method or as a keyhole cancer diagnostic technique. Cytology is therefore important in both cancer prevention as well as diagnosis and staging of manifest disease.
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Molecular Pathology

Molecular pathology is using techniques derived from molecular biology (e.g. PCR, CISH, FISH, Next-generation sequencing NGS) as an important adjunct of histological diagnosis. It can provide for subclassification of disease and for prognostication. Infectious agents are rapidly detected and identified. In familial tumors it provides the basis for genetic counselling.
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Molecular Tumor Profiling (Foundation One Service, Next-Generation Sequencing)
FoundationOne® provides a comprehensive molecular tumour profile for solid tumors which can support doctors in their decisions regarding the treatment of cancer patients by detecting genetic changes associated with cancer.
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Immune histochemistry (In situ Techniques)
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Electron microscopy
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Centralized Tissue and Cell Biobank USZ
Autopsies are performed for quality assurance and for medical education.
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The Institute of Pathology and Molecular Pathology has an accreditation in accordance with the standard ISO/IEC 17020 and ISO/IEC 17025.

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